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Anti-ADA2 Antibody (CAB20265)

SKU:
CAB20265
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PAN
ADGF
CECR1
IDGFL
SNEDS
VAIHS
€359
Frequently bought together:

Description

Product Name:ADA2 Rabbit pAb
Product Code:CAB20265
Size:50uL, 100uL
Synonyms:PAN, ADGF, CECR1, IDGFL, SNEDS, VAIHS
Applications:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ADA2.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:Rat plasma
Immunogen:Recombinant protein of human ADA2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:51816
Uniprot:Q9NZK5
Observed MW:59KDa
UniProt Protein Function:CECR1: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. Belongs to the adenosine and AMP deaminases family. ADGF subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.5.4.4; Hydrolase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: cytosol; extracellular region; extracellular space

Molecular Function:adenosine deaminase activity; adenosine receptor binding; growth factor activity; protein homodimerization activity; proteoglycan binding; zinc ion binding

Biological Process: adenosine catabolic process; cellular protein metabolic process; hypoxanthine salvage; inosine biosynthetic process

Disease: Polyarteritis Nodosa, Childhood-onset; Sneddon Syndrome

NCBI Summary:This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Code:Q9NZK5
NCBI GenInfo Identifier:122065151
NCBI Gene ID:51816
NCBI Accession:Q9NZK5.2
UniProt Secondary Accession:Q9NZK5,Q6ICF1, Q86UB6, Q8NCJ2, Q96K41, A8K9H4,
UniProt Related Accession:Q9NZK5
Molecular Weight:30,668 Da
NCBI Full Name:Adenosine deaminase CECR1
NCBI Synonym Full Names:cat eye syndrome chromosome region, candidate 1
NCBI Official Symbol:CECR1  
NCBI Official Synonym Symbols:PAN; ADA2; ADGF; IDGFL; SNEDS  
NCBI Protein Information:adenosine deaminase CECR1
UniProt Protein Name:Adenosine deaminase CECR1
UniProt Synonym Protein Names:Cat eye syndrome critical region protein 1
Protein Family:Adenosine deaminase
UniProt Gene Name:CECR1  

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