The ACVR1B Monoclonal Antibody (CAB2279) is a valuable tool for researchers studying the ACVR1B protein, a receptor belonging to the TGF-beta superfamily involved in various cellular processes, including cell growth and differentiation. This antibody, produced in mice, exhibits high specificity towards human samples and is suitable for use in applications such as immunofluorescence and flow cytometry.ACVR1B plays a vital role in signal transduction pathways related to cell proliferation and differentiation, making it a key player in development and disease.
Dysregulation of ACVR1B has been implicated in conditions such as cancer, cardiovascular diseases, and skeletal disorders, highlighting its potential as a therapeutic target. By utilizing the ACVR1B Monoclonal Antibody, researchers can gain valuable insights into the function of this receptor and its implications in various pathological conditions.
Product Name:
ACVR1B Rabbit Monoclonal Antibody
SKU:
CAB2279
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACVR1B (P36896).
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
91
Clone Number:
ARC1899
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACVR1B Rabbit mAb (CAB2279) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
