ACVR1 Rabbit Monoclonal Antibody (CAB19274)
- SKU:
- CAB19274
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ACVR1
- ACTRI
- ACVR1A
- ACVRLK2
- ALK2
- FOP
- SKR1
- TSRI
- activin receptor type-1
- Research Area:
- Cell Biology
Description
Product Name: | ACVR1 Rabbit Monoclonal Antibody |
SKU: | CAB19274 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 410-509 of human ACVR1 (Q04771). |
Sequence: | VLWE VARR MVSN GIVE DYKP PFYD VVPN DPSF EDMR KVVC VDQQ RPNI PNRW FSDP TLTS LAKL MKEC WYQN PSAR LTAL RIKK TLTK IDNS LDKL KTDC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; ACVR1 |
Positive Sample: | 293T,A549,MCF7,Mouse brain,Rat testis,Rat brain |
Conjugate: | Unmodified |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Purification Method: | Affinity purification |
Gene ID: | 90 |
Clone Number: | ARC2449 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |