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ACVR1 Rabbit Monoclonal Antibody (CAB19274)

SKU:
CAB19274
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ACVR1
ACTRI
ACVR1A
ACVRLK2
ALK2
FOP
SKR1
TSRI
activin receptor type-1
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ACVR1 Rabbit Monoclonal Antibody
SKU:CAB19274
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 410-509 of human ACVR1 (Q04771).
Sequence:VLWE VARR MVSN GIVE DYKP PFYD VVPN DPSF EDMR KVVC VDQQ RPNI PNRW FSDP TLTS LAKL MKEC WYQN PSAR LTAL RIKK TLTK IDNS LDKL KTDC
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; ACVR1
Positive Sample:293T,A549,MCF7,Mouse brain,Rat testis,Rat brain
Conjugate:Unmodified
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:57kDa
Observed MW:57kDa

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Purification Method:Affinity purification
Gene ID:90
Clone Number:ARC2449
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of Mouse brain, using ACVR1 antibody (CAB19274) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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