Activator protein 2 (AP-2/TFAP2A) Rabbit Monoclonal Antibody (CAB2294)
The Anti-Activator Protein 2 (AP-2) TFAP2A Antibody (CAB2294) is a valuable tool for researchers studying the transcription factor TFAP2A, also known as AP-2. This antibody, generated in rabbits, is highly specific and sensitive for detecting TFAP2A in human samples, making it ideal for use in experiments such as Western blotting.TFAP2A is a crucial transcription factor involved in the regulation of gene expression, particularly in the development of tissues and organs. It plays a key role in various biological processes, including cell proliferation, differentiation, and apoptosis.
Dysregulation of TFAP2A has been implicated in various diseases, including cancer and developmental disorders.By using the Anti-Activator Protein 2 (AP-2) TFAP2A Antibody (CAB2294), researchers can gain insights into the function and regulation of TFAP2A in different cellular contexts. This antibody provides a reliable tool for studying the role of TFAP2A in various physiological and pathological processes, advancing our understanding of gene regulation and potential therapeutic targets.
Product Name:
Activator protein 2 (AP-2/TFAP2A) Rabbit Monoclonal Antibody
SKU:
CAB2294
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Activator protein 2 (AP-2/TFAP2A) (P05549).
AP-2; BOFS; AP2TF; TFAP2; AP-2alpha; Activator protein 2 (AP-2/TFAP2A)
Positive Sample:
HeLa,PC-3,NIH/3T3
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
48kDa
Observed MW:
48kDa
The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7020
Clone Number:
ARC1905
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Activator protein 2 (AP-2/TFAP2A) Rabbit mAb (CAB2294) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
