The Anti-ACTC1 Antibody (CAB6507) is a highly specific antibody designed for research involving ACTC1, a protein that plays a key role in muscle contraction. This polyclonal antibody, raised in rabbits, is validated for use in various applications, including Western blot and immunohistochemistry.ACTC1, also known as cardiac muscle alpha actin, is primarily expressed in cardiac muscle cells and is essential for maintaining the structural integrity of the sarcomere. Dysregulation of ACTC1 has been linked to various cardiac disorders, making it a crucial target for research in cardiology and muscle biology.
This antibody binds specifically to the ACTC1 protein, allowing for accurate detection and analysis in different cell types and tissues. Its high reactivity with human samples makes it an ideal tool for studying the function and regulation of ACTC1 in normal and diseased states. Researchers interested in understanding the molecular mechanisms underlying cardiac muscle function and dysfunction will find the Anti-ACTC1 Antibody (CAB6507) invaluable for their studies.
Product Name:
ACTC1 Rabbit Polyclonal Antibody
SKU:
CAB6507
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACTC1 (NP_005150.1).
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).
Purification Method:
Affinity purification
Gene ID:
70
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACTC1 Rabbit pAb (CAB6507) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
