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ACHA4 Rabbit Monoclonal Antibody (CAB0350)

SKU:
CAB0350
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ACHA4 Rabbit Monoclonal Antibody
SKU:CAB0350
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ACHA4 (P43681).
Sequence:PEAD GQAA GALA SRNT HSAE LPPP DQPS PCKC TCKK EPSS VSPS ATVK TRST KAPP PHLP LSPA LTRA VEGV QYIA DHLK AEDT DFSV KEDW KYVA MVID R
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; ACHA4
Positive Sample:SH-SY5Y,U-251MG,C6,Mouse liver,Mouse brain,Rat testis
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Lipid-anchor, Multi-pass membrane protein, postsynaptic cell membrane, synapse.
Calculated MW:70kDa
Observed MW:70kDa

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:1137
Clone Number:ARC1822
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using ACHA4 Rabbit mAb (CAB0350) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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