The Anti-ACHA4 Antibody (CAB0350) is a high-quality research tool designed for the detection and analysis of ACHA4, a key protein involved in immune regulation. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ACHA4 protein, this antibody enables researchers to study immune responses and their implications in various cell types.ACHA4, also known as a cell surface molecule with immunomodulatory properties, is critical for maintaining immune homeostasis by regulating inflammatory responses and inhibiting allergic reactions.
This antibody is an essential tool for investigating the role of ACHA4 in immune function, making it suitable for studies in immunology and cancer research. Understanding the mechanisms underlying ACHA4's activity is crucial for developing targeted therapies for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Product Name:
ACHA4 Rabbit Monoclonal Antibody
SKU:
CAB0350
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ACHA4 (P43681).
Sequence:
PEAD GQAA GALA SRNT HSAE LPPP DQPS PCKC TCKK EPSS VSPS ATVK TRST KAPP PHLP LSPA LTRA VEGV QYIA DHLK AEDT DFSV KEDW KYVA MVID R
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1137
Clone Number:
ARC1822
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ACHA4 Rabbit mAb (CAB0350) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
