The Anti-Acetyl Histone H3 (K23) Antibody (CAB2771) is a vital tool for researchers studying histone modifications and their impact on gene expression. This antibody, produced using advanced technology, specifically targets acetylation at lysine 23 on histone H3, a key modification involved in chromatin structure and transcriptional regulation.Histone acetylation at lysine 23 has been linked to various biological processes, including DNA repair, cell cycle regulation, and development. This antibody is highly specific and validated for use in various applications, including immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry.
Researchers can use this antibody to investigate the role of histone H3 acetylation at lysine 23 in disease states such as cancer, neurodegenerative disorders, and cardiovascular diseases. By studying the effects of this histone modification, scientists can gain insights into the epigenetic mechanisms underlying these conditions and potentially identify new therapeutic targets.
Product Name:
Acetyl-Histone H3-K23 Rabbit Monoclonal Antibody
SKU:
CAB2771
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat,Other (Wide Range Predicted)
Immunogen:
A synthetic acetylated peptide around K27 of human Histone H3 (P68431).
DB,1:500 - 1:2000 WB,1:10000 - 1:120000 IHC-P,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsIF/ICC,1:50 - 1:200 ChIP,2μg antibody for 5μg-10μg of Chromatin
Positive Sample:
HeLa TSA, NIH/3T3 TSA ,C6 TSA
Conjugate:
Unconjugated
Cellular Localization:
Chromosome, Nucleus
Calculated MW:
15kDa
Observed MW:
17kDa
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Purification Method:
Affinity purification
Gene ID:
8290/8350
Clone Number:
ARC53670
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Dot-blot analysis of all sorts of peptides using Acetyl-Histone H3-K27 Rabbit mAb (CAB2771) at 1:200000 dilution.
