The Anti-ACE2 Monoclonal Antibody is a specialized antibody designed for research involving the ACE2 receptor, a critical cell surface molecule involved in the renin-angiotensin system and implicated in various diseases, including COVID-19. This monoclonal antibody, produced using hybridoma technology, is highly specific and sensitive for detecting ACE2 protein expression in human samples.The ACE2 receptor plays a crucial role in regulating blood pressure, cardiovascular function, and inflammation by cleaving angiotensin II to angiotensin-(1-7). Its overexpression has been linked to increased susceptibility to SARS-CoV-2, the virus responsible for COVID-19.
This antibody binds specifically to the ACE2 protein, enabling accurate detection and analysis in various cell types and tissues, making it an invaluable tool for research in virology, immunology, and therapeutic development.Understanding the role of ACE2 in viral infections and its potential as a therapeutic target is essential for developing strategies to combat COVID-19 and other diseases. This monoclonal antibody provides researchers with a reliable tool for investigating the functions and interactions of ACE2, advancing our knowledge of the molecular mechanisms underlying infection and immune response modulation.
Product Name:
ACE2 Rabbit Monoclonal Antibody
SKU:
CAB4612
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-740 of human ACE2 (NP_068576.1).
Hep G2,Mouse brain,Mouse heart,Rat brain,Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein.
Calculated MW:
92kDa
Observed MW:
100kDa/120kDa
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
Purification Method:
Affinity purification
Gene ID:
59272
Clone Number:
ARC50948
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACE2 Rabbit mAb (CAB4612) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
