The Anti-ACC1 Antibody (CAB19627) offered by Assay Genie is a high-quality polyclonal antibody designed for research involving Acc1, an essential enzyme in lipid metabolism. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the Acc1 protein, allowing for detection and analysis in various cell types, making it an ideal tool for studies in metabolism and lipid biology.Acc1, also known as Acetyl CoA Carboxylase 1, plays a crucial role in fatty acid synthesis and regulation of lipid metabolism.
Dysregulation of Acc1 has been linked to various metabolic disorders, including obesity, diabetes, and cardiovascular diseases. Understanding the function of Acc1 is essential for developing therapeutic strategies to target metabolic disorders and related conditions.Overall, the Anti-ACC1 Antibody (CAB19627) is a valuable tool for researchers studying lipid metabolism, metabolic disorders, and related diseases. Its high reactivity and specificity make it a reliable option for Western blot applications and other research techniques in the field of metabolism and lipid biology.
Product Name:
ACC1 Rabbit Monoclonal Antibody
SKU:
CAB19627
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ACC1 (Q13085).
actin cytoskeleton, cytosol, fibrillar center, mitochondrion
Calculated MW:
266kDa
Observed MW:
277kDa
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
31
Clone Number:
ARC2201
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACC1 Rabbit mAb (CAB19627) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
