ACC1 Rabbit Monoclonal Antibody (CAB19627)
- SKU:
- CAB19627
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ACC
- ACAC
- ACC1
- ACCA
- ACACAD
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | ACC1 Rabbit Monoclonal Antibody |
SKU: | CAB19627 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ACC1 (Q13085). |
Sequence: | RLAK QSRH LEVQ ILAD QYGN AISL FGRD CSVQ RRHQ KIIE EAPA TIAT PAVF EHME QCAV KLAK MVGY VSAG TVEY LYSQ DGSF YFLE LNPR LQVE HPCT E |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha |
Positive Sample: | HeLa,HepG2,C6,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | actin cytoskeleton, cytosol, fibrillar center, mitochondrion |
Calculated MW: | 266kDa |
Observed MW: | 277kDa |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 31 |
Clone Number: | ARC2201 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |