67kDa Laminin Receptor Rabbit Monoclonal Antibody (CAB5968)
- SKU:
- CAB5968
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- 37LRP
- 67LR
- ICAS
- LAMBR
- LAMR1
- LBP
- LBP/p40
- LRP
- LRP/LR
- NEM/1CHD4
- SA
- lamR
- p40
Description
Product Name: | 67kDa Laminin Receptor Rabbit Monoclonal Antibody |
SKU: | CAB5968 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 196-295 of human Laminin Receptor (P08865). |
Sequence: | EVMP DLYF YRDP EEIE KEEQ AAAE KAVT KEEF QGEW TAPA PEFT ATQP EVAD WSEG VQVP SVPI QQFP TEDW SAQP ATED WSAA PTAQ ATEW VGAT TDWS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | SA; LBP; LRP; p40; uS2; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4; 67kDa Laminin Receptor |
Positive Sample: | PC-12,A-549,BxPC-3,Raji,RAW264.7,Rat pancreas |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytosol, Cytosolic ribosome, Extracellular exosome, Nucleoplasm, Nucleus, Plasma membrane |
Calculated MW: | 33kDa |
Observed MW: | 45kDa |
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3921 |
Clone Number: | ARC2109 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |