The Anti-5T4 Antibody (CAB19541) is a valuable tool for researchers studying the 5T4 protein, which is highly expressed in various cancer types and involved in tumor growth and metastasis. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in immunohistochemistry and flow cytometry applications.The 5T4 protein, also known as trophoblast glycoprotein, is a promising target for cancer therapies due to its selective expression on cancer cells and limited distribution in normal tissues. By binding to the 5T4 protein, this antibody allows for precise detection and analysis of 5T4 expression in cancer cells, aiding in the understanding of its role in tumor progression and potential as a therapeutic target.
Research on the 5T4 protein has shown its involvement in tumor cell proliferation, invasion, and resistance to therapy, making it a potential biomarker for cancer prognosis and a target for novel anti-cancer treatments. The Anti-5T4 Antibody provides researchers with a reliable tool for investigating the biology of 5T4-positive tumors and developing strategies to combat cancer progression.
Product Name:
5T4 Rabbit Monoclonal Antibody
SKU:
CAB19541
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 321-420 of human 5T4 (Q13641).
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
Purification Method:
Affinity purification
Gene ID:
7162
Clone Number:
ARC2167
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using 5T4 Rabbit mAb (CAB19541) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
