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5-Hydroxymethylcytosine/ 5hmC Rabbit Polyclonal Antibody (CAB20140)

SKU:
CAB20140
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
hm5C
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:5-Hydroxymethylcytosine/ 5hmC Rabbit Polyclonal Antibody
SKU:CAB20140
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat,Other (Wide Range Predicted)
Immunogen:Chemical compounds corresponding to 5-hydroxymethylcytidine / hm5C.
Tested Applications:ELISA DB
Recommended Dilution:DB,1:500 - 1:2000
Synonyms:5-hmC; 5hmc; 5-HydroxyMethyl cytidine; hm5c; 5-Hydroxymethylcytosine/ 5-hmC
Observed MW:Refer to figures

In mammalian genomes, 5-mC can be enzymatically oxidized to 5-hmC (5-hydroxymethylcytosine). This modification is suggested to be an intermediate between methylation and demethylation of the genome. Occupancy of 5-hmC correlates with inactive or non-productive promoters (PMID: 21925312). 5-hmC pattern is different from 5-methylcytosine (5-mC) in many instances(PMID: 21610077).

Purification Method:Affinity purification
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageDot-blot analysis of 5-Hydroxymethylcytosine(5-hmC),5-Methylcytosine (5mC) and unmodified adenosine using 5-Hydroxymethylcytosine/ 5-hmC antibody (CAB20140) at 1:500/1:2000 dilution.m5C 1 - 5’CAGTAACTGTGGTCCGGTAACTGACTTGCA3’m5C 2 - 5’CAGTAACTGTGGTC/i5MedC/GGTAACTGACTTGCA3’

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