The Anti-4-1BBL (CD137L) Antibody (CAB3386) is a high-quality research tool designed for studying the 4-1BBL (CD137L) protein, a co-stimulatory molecule involved in immune regulation and activation. This polyclonal antibody is raised in rabbits and is highly reactive with human samples, making it suitable for use in Western blot applications for the detection and analysis of the CD137L protein in various cell types.The CD137L protein, also known as tumor necrosis factor ligand superfamily member 9 (TNFSF9), plays a crucial role in immune responses, particularly in the regulation of T cell activation and proliferation.
It is implicated in the modulation of immune function in various physiological and pathological conditions, making it a valuable target for research in immunology, cancer biology, and autoimmune diseases.By utilizing the Anti-4-1BBL (CD137L) Antibody (CAB3386), researchers can gain insights into the molecular mechanisms underlying immune regulation and potentially develop novel therapeutic approaches targeting the CD137L pathway. This antibody is a valuable tool for advancing our understanding of immune responses and identifying potential treatment strategies for various diseases.
Product Name:
4-1BBL/CD137L Rabbit Monoclonal Antibody
SKU:
CAB3386
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 155-254 of human 4-1BBL/CD137L (P41273).
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Purification Method:
Affinity purification
Gene ID:
8744
Clone Number:
ARC1963
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using 4-1BBL/CD137L Rabbit mAb (CAB3386) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
