The Anti-2'-O-Methyluridine (UM) Antibody (CAB20695) is a valuable tool for researchers studying RNA modifications. This polyclonal antibody, produced in rabbits, specifically targets the 2'-O-Methyluridine (UM) modification, allowing for precise detection and analysis of UM-containing RNA molecules. Validated for use in various applications such as immunoprecipitation and RNA sequencing, this antibody offers high specificity and sensitivity in identifying UM-modified RNAs.The 2'-O-Methyluridine modification is known to play important roles in RNA stability, translation efficiency, and RNA-protein interactions.
By using the Anti-2'-O-Methyluridine (UM) Antibody, researchers can gain insights into the biological functions of UM-modified RNAs in processes such as gene expression regulation, RNA metabolism, and cellular signaling pathways. This antibody is essential for advancing our understanding of RNA modifications and their impact on various cellular processes, making it an indispensable tool for RNA research.
Product Name:
2'-O-methyluridine(Um) Monoclonal Antibody
SKU:
CAB20695
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Species independent
Immunogen:
Um
Sequence:
Um c onju gate d to KLH
Tested Applications:
ELISADB
Recommended Dilution:
DB,1:500 - 1:1000
Synonyms:
Um; 2'-O-methyluridine; 2'-O-methyluridine(Um)
Positive Sample:
2'-O-methyluridine(Um)
Conjugate:
Unconjugated
Observed MW:
Refer to figures
Ribose methylation is among the most ubiquitous modifications found in RNA. 2'-O-methyluridine is found in rRNA, snRNA, snoRNA and tRNA of Archaea, Bacteria, and Eukaryota. Moreover, 2'-O-methylribonucleosides are promising starting materials for the production of nucleic acid-based drugs. The chemical modification 2'-O-methyl of nucleosides is often used to increase siRNA stability towards nuclease activities.
Purification Method:
Affinity purification
Gene ID:
CAS: 2140-76-3
Clone Number:
ARC50750
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Dot-blot analysis of 2'-O-methyluridine(Um) and unmodified uridine using 2'-O-methyluridine(Um) Rabbit mAb antibody (CAB20695) at 1:1000 dilution.2'-O-methyluridine : Biotin-5'UGACAACUACAGAC(Um)3'unmodified uridine : Biotin-5'UGACAACUACAGACU3'
