2'-O-methyluridine(Um) Rabbit Polyclonal Antibody (CAB20305)
- SKU:
- CAB20305
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- Um
- 2'-O-methyluridine
Description
Product Name: | 2'-O-methyluridine(Um) Rabbit Polyclonal Antibody |
SKU: | CAB20305 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Species independent |
Immunogen: | Um |
Sequence: | Um c onju gate d to KLH |
Tested Applications: | ELISA DB |
Recommended Dilution: | DB,1:500 - 1:2000 |
Synonyms: | Um; 2'-O-methyluridine; 2'-O-methyluridine(Um) |
Conjugate: | Unconjugated |
Observed MW: | Refer to figures |
RNA methylation plays a significant regulatory role in various of physiological activities and it has gradually become a hotspot of epigenetics in the past decade. 2'-O-methyladenosine (Am), 2'-O-methylguanosine (Gm),2'-O-methylcytidine (Cm),2'-O-methyluridine (Um),N 6-methyladenosine (m6A), N 1-methylguanosine (m1G),5-methylcytidine (m5C),and 5-methyluridine (m5U) are representative 2'-O-methylation and base-methylation modified epigenetic marks of RNA. 2'-O-methyltransferase is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase, using S-adenosyl-L-methionine as a substrate. Through its interaction with other modified nucleosides, 2'-O-methylguanosine is thought to stabilize the structure of the tRNA.
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |