The ANP32C Polyclonal Antibody (PAC018652) is a valuable tool for researchers studying ANP32C, a protein known for its involvement in cellular processes such as apoptosis and DNA damage response. This antibody, developed in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the ANP32C protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for investigations in cell biology and cancer research.ANP32C, also known as acidic leucine-rich nuclear phosphoprotein 32 family member C, plays a crucial role in maintaining cellular homeostasis and responding to DNA damage signals.
Its functions in these processes make it a promising target for research on diseases like cancer, where dysregulation of cellular pathways can lead to uncontrolled growth and tumor formation. By gaining insights into the role of ANP32C, researchers can better understand the mechanisms underlying disease development and potentially identify new therapeutic approaches.
Antibody Name:
ANP32C Antibody (PACO18652)
Antibody SKU:
PACO18652
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ANP32C
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18652(ANP32C Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18652(ANP32C Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid, sequence to PP32 and are part of the same acid, c nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid, region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.
Synonyms:
acid, c (leucine-rich) nuclear phosphoprotein 32 family, member C
UniProt Protein Function:
ANP32C: Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 4q32.3
UniProt Protein Details:
NCBI Summary:
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]
