The ANO9 Polyclonal Antibody (PACO04096) is an essential tool for researchers studying ANO9, a member of the Anoctamin family of proteins known to regulate calcium-activated chloride channels. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for Western blot applications. By targeting the ANO9 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in the fields of physiology, neuroscience, and cell biology.
ANO9 is known for its role in regulating calcium signaling and chloride ion transport, processes essential for cellular excitability, fluid secretion, and other physiological functions. Dysregulation of ANO9 has been implicated in various diseases, including cystic fibrosis, cardiac arrhythmias, and neurological disorders. By studying the function and expression of ANO9, researchers can gain insights into these conditions and potentially identify new therapeutic targets for treatment.
Antibody Name:
ANO9 Antibody
Antibody SKU:
PACO04096
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Anoctamin-9.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ANO9; PIG5; TMEM16J; TP53I5; Anoctamin-9; Transmembrane protein 16J; Tumor protein p53-inducible protein 5; p53-induced gene 5 protein
UniProt Protein Function:
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]
