The ANO7 Polyclonal Antibody (PAC023753) is a vital tool for researchers studying ANO7, a protein involved in the regulation of calcium signaling and ion transport in cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human ANO7 samples, making it suitable for use in Western blot experiments. By targeting the ANO7 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in molecular biology and cell physiology.ANO7, also known as TMEM16G, is a member of the transmembrane 16 (TMEM16) protein family, implicated in diverse cellular functions such as chloride ion transport and lipid scrambling. Its role in calcium-dependent signaling pathways makes ANO7 a key player in processes like neurotransmission and muscle contraction.
Researchers interested in understanding the mechanisms underlying these physiological functions will find the ANO7 Polyclonal Antibody indispensable for their studies.With its ability to specifically recognize and target ANO7 in human samples, this antibody is a valuable tool for unraveling the intricate functions of this protein in various biological processes. By facilitating the precise detection and analysis of ANO7, researchers can gain deeper insights into its role in cellular function and potentially uncover new therapeutic targets for conditions related to calcium signaling dysregulation.
Synthesized peptide derived from C-terminal of human TM16G.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from LOVO cells, using TM16G antiobdy.
Immunofluorescence analysis of HepG2 cells, using TM16G antibody.
Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using TM16G antibody.
Background:
Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
Synonyms:
New gene expressed in prostate; Prostate cancer-associated protein 5; IPCA-5; Dresden-transmembrane protein of the prostate; D-TMPP
UniProt Protein Function:
ANO7: May act as a calcium-activated chloride channel. May play a role in cell-cell interactions. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, ion channel; Channel, chloride; Calcium-binding; Membrane protein, integral; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2q37.3Cellular Component: endoplasmic reticulum; integral to membrane; plasma membrane; intracellular; nucleus; cytosol; cell junctionMolecular Function: phospholipid scramblase activity; intracellular calcium activated chloride channel activityBiological Process: chloride transport; lipid transport; transmembrane transport
UniProt Protein Details:
NCBI Summary:
This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]
NGEP; DTMPP; IPCA5; D-TMPP; IPCA-5; PCANAP5; TMEM16G; PCANAP5LÂ Â
NCBI Protein Information:
anoctamin-7; transmembrane protein 16G; prostate cancer associated protein 5; Dresden-transmembrane protein of the prostate
UniProt Protein Name:
Anoctamin-7
UniProt Synonym Protein Names:
Dresden transmembrane protein of the prostate; D-TMPP; IPCA-5; New gene expressed in prostate; Prostate cancer-associated protein 5; Transmembrane protein 16G
