The ANO6 Polyclonal Antibody (CAB12050) is a crucial tool for researchers studying ANO6, a protein involved in calcium-activated chloride channel activity and cell volume regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ANO6 protein, this antibody enables accurate detection and analysis of ANO6 in various cell types, making it a valuable asset for studies in physiology and cell biology.
ANO6, also known as TMEM16F, is essential for maintaining cellular homeostasis through its role in chloride ion transport and the regulation of cell volume. Dysregulation of ANO6 has been implicated in various diseases, including cystic fibrosis, hypertension, and cancer. By studying ANO6 function with the help of this antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
Product Name:
ANO6 Rabbit Polyclonal Antibody
SKU:
CAB12050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 750-830 of human ANO6 (NP_001020527.2).
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
196527
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ANO6 Rabbit pAb (CAB12050) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
