The ANO3 Polyclonal Antibody (PACO07742) is a crucial tool for researchers studying ANO3, a member of the anoctamin family of proteins implicated in various physiological processes, including calcium-activated chloride channel activity. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ANO3 protein, this antibody allows for the detection and analysis of ANO3 expression in different cell types, making it well-suited for investigations in neuroscience, cardiology, and other fields where ANO3 function is of interest.
ANO3, also known as TMEM16C, is involved in the regulation of neuronal excitability, muscle contraction, and other cellular functions through its ion channel activity. Its role in calcium-dependent processes makes ANO3 a potential target for research on neurological disorders, cardiac arrhythmias, and other conditions that involve abnormal ion channel function. Understanding the function of ANO3 is essential for developing targeted therapies that modulate ion channel activity and contribute to the treatment of related diseases.
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (). Does not exhibit calcium-activated chloride channel (CaCC) activity.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
