The Annexin A7 Polyclonal Antibody (CAB3733) is a valuable tool for researchers studying Annexin A7, a protein involved in various cellular processes such as membrane dynamics and intracellular signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Annexin A7 is known for its role in calcium-dependent membrane binding and its participation in various signaling pathways that regulate cell growth and apoptosis. The Annexin A7 Polyclonal Antibody binds specifically to Annexin A7, allowing for its detection and analysis in different cell types.
This makes it a versatile tool for research in areas such as cell biology, neuroscience, and cancer research.With its ability to target Annexin A7, this antibody is instrumental in studying the function and regulation of this important protein. By understanding the role of Annexin A7 in cellular processes, researchers can gain insights into its involvement in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. The Annexin A7 Polyclonal Antibody is a valuable resource for advancing knowledge in these areas and developing potential therapeutic strategies.
Product Name:
ANXA7 Rabbit Polyclonal Antibody
SKU:
CAB3733
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 237-466 of human ANXA7 (NP_001147.1).
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
Purification Method:
Affinity purification
Gene ID:
310
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ANXA7 antibody (CAB3733) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
