The ANKRD54 Polyclonal Antibody (PAC015446) is specifically designed for research involving ANKRD54, a protein involved in cellular processes such as cell cycle regulation and DNA repair. The antibody, generated in rabbits, is highly reactive with human samples and is validated for use in Western blot applications, allowing for the detection and analysis of ANKRD54 in various cell types.ANKRD54 is a critical protein in the regulation of DNA damage response pathways, making it a key player in maintaining genomic stability. Its role in cell cycle control also suggests potential implications in cancer development and progression.
Studying the function of ANKRD54 can provide valuable insights into the mechanisms underlying cancer biology and may lead to the development of novel therapeutic strategies targeting this protein.Overall, the ANKRD54 Polyclonal Antibody is an essential tool for researchers focusing on DNA repair, cell cycle regulation, and cancer biology. Its high specificity and reactivity make it a reliable resource for studies aiming to unravel the complexities of ANKRD54 function in both normal and disease states.
Antibody Name:
ANKRD54 Antibody (PACO15446)
Antibody SKU:
PACO15446
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human ANKRD54
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15446(ANKRD54 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15446(ANKRD54 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN By similarity. Forms a multiprotein complex with LYN and HCLS1 By similarity. Interacts with TSN2, VAV1, DBNL AND LASP1.
Synonyms:
ankyrin repeat domain 54
UniProt Protein Function:
ANKRD54: Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 22q13.1Cellular Component: cytoplasm; midbody; nucleusMolecular Function: protein bindingBiological Process: positive regulation of erythrocyte differentiation
