The ANKRD11 Antibody (PAC049218) is a highly specific tool for researchers studying the ANKRD11 protein, a key player in chromatin remodeling and transcriptional regulation. This polyclonal antibody, derived from rabbits, is particularly effective in detecting ANKRD11 in human samples and has been validated for use in Western blotting applications.ANKRD11 is a critical regulator of gene expression and is involved in various cellular processes, including cell growth, differentiation, and development. Dysregulation of ANKRD11 has been implicated in a variety of disorders, including neurodevelopmental disorders and cancer.
Therefore, understanding the function and expression of ANKRD11 is essential for unraveling its role in these diseases and for developing potential therapeutic strategies.In summary, the ANKRD11 Antibody (PAC049218) is a reliable tool for researchers looking to investigate the role of ANKRD11 in health and disease, with potential applications in fields such as genetics, developmental biology, and oncology.
Antibody Name:
ANKRD11 Antibody (PACO49218)
Antibody SKU:
PACO49218
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Ankyrin repeat domain-containing protein 11 protein (1002-1276AA)
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis (By similarity).
ANKRD11: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Defects in ANKRD11 are the cause of KBG syndrome (KBGS). A syndrome characterized by macrodontia of the upper central incisors, distinctive craniofacial findings, short stature, skeletal anomalies, and neurologic involvement that includes global developmental delay, seizures, and intellectual disability.Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 16q24.3Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleusBiological Process: in utero embryonic development; skeletal morphogenesis; multicellular organism growth; tissue homeostasis; odontogenesis of dentine-containing teethDisease: Kbg Syndrome
UniProt Protein Details:
NCBI Summary:
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012]
