The AnKRA2 Polyclonal Antibody (PAC018563) is a valuable tool for researchers studying the AnKRA2 protein and its involvement in cellular processes. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blotting applications. By specifically binding to the AnKRA2 protein, this antibody allows for the detection and analysis of AnKRA2 in various cell types, making it ideal for studies in molecular biology and cell biology research.AnKRA2, also known as a novel kinase regulator, plays a key role in regulating kinase activity and signal transduction pathways within cells. Its functions in cell signaling make it a promising target for research aimed at understanding various cellular processes and diseases.
By investigating the role of AnKRA2, researchers can gain insights into the mechanisms underlying cell signaling and potentially identify new therapeutic targets for conditions such as cancer, neurodegenerative disorders, and metabolic diseases. Overall, the AnKRA2 Polyclonal Antibody is a valuable tool for researchers interested in studying the functions and regulation of the AnKRA2 protein in cellular processes and disease states. Its high reactivity towards human samples and validated performance in Western blot applications make it a reliable reagent for various research applications.
Antibody Name:
ANKRA2 Antibody (PACO18563)
Antibody SKU:
PACO18563
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ANKRA2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18563(ANKRA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18563(ANKRA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This protein may facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery. ANKRA2 is a megalin- and BKCa potassium channel-interacting factor. It is a protein known to interact with HDAC4 and HDAC5.ANKRA2 is important for transcriptional repression by AhRR.
Synonyms:
ankyrin repeat, family A (RFXANK-like), 2
UniProt Protein Function:
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin ().
