The ANKMY2 Polyclonal Antibody (PAC01544) is a valuable tool for researchers studying ANKMY2, a protein involved in various cellular functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the ANKMY2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and molecular research.ANKMY2, also known as ankyrin repeat and MYND domain-containing protein 2, is known to play a role in diverse cellular processes such as protein-protein interactions and gene regulation.
Its involvement in these functions highlights its importance in understanding various biological mechanisms. Researchers studying ANKMY2 may gain insights into its potential implications in diseases such as cancer, neurological disorders, and developmental abnormalities. By elucidating the functions of ANKMY2, researchers can pave the way for innovative therapeutic strategies targeting this protein.
Antibody Name:
ANKMY2 Antibody (PACO15444)
Antibody SKU:
PACO15444
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ANKMY2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15444(ANKMY2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15444(ANKMY2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
ANKMY2 (ankyrin repeat and MYND domain containing 2) is a 441 amino acid, protein that contains three ANK repeats and one MYND-type zinc finger. Encoded by a gene that maps to human chromosome 7p21.1, ANKMY2 is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito and Caenorhabditis elegans. Downregulation of ANKMY2, associated with frequent deletions of human chromosome 7p22.1, indicate that ANKMY2 may role a role in the pathogenesis of natural killer (NK)-cell malignancies. ANKMY2 is also upregulated by enforced expression of Hox11, which functions broadly to hinder hemopoiesis, diverts differentiation to an alternative fate and promotes pre-leukaemic states.
Synonyms:
ankyrin repeat and MYND domain containing 2
UniProt Protein Function:
ANKMY2: May be involved in the trafficking of signaling proteins to the cilia.Chromosomal Location of Human Ortholog: 7p21Cellular Component: ciliumMolecular Function: metal ion binding
