The ANGPTL4 Polyclonal Antibody (CAB2011) is specifically designed for research involving ANGPTL4, a crucial player in lipid metabolism and angiogenesis regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the ANGPTL4 protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent tool for studies in metabolic disorders, cardiovascular diseases, and cancer research.
ANGPTL4, also known as fasting-induced adipose factor, is involved in lipid metabolism by regulating triglyceride levels and promoting lipolysis in adipose tissue. Additionally, ANGPTL4 has been shown to inhibit angiogenesis, making it a potential therapeutic target for cancer treatment. Understanding the role of ANGPTL4 in metabolic and vascular processes is crucial for developing novel therapies targeting these pathways.
Product Name:
ANGPTL4 Rabbit Polyclonal Antibody
SKU:
CAB2011
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-170 of human ANGPTL4 (NP_647475.1).
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
Purification Method:
Affinity purification
Gene ID:
51129
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using ANGPTL4 Rabbit pAb (CAB2011) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
