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ANGPTL3 Monoclonal Antibody [P1D10AT] (CPAB0057)

SKU:
CPAB0057
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P1D10AT
Applications:
WB
ELISA
€149

Description

system_update_alt Datasheet

ANGPTL3 Monoclonal Antibody [P1D10AT] (CPAB0057)

The ANGPTL3 Polyclonal Antibody (CPAB0057) is a vital tool for researchers studying ANGPTL3, a protein involved in lipid metabolism and cardiovascular health. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it a reliable choice for Western blot applications. By binding to the ANGPTL3 protein, this antibody enables precise detection and analysis in a variety of cell types, offering valuable insights into lipid regulation and potential therapeutic targets for cardiovascular diseases.

ANGPTL3 is a key player in lipid metabolism, functioning to regulate triglyceride levels and influence cholesterol homeostasis. Research suggests its potential role in cardiovascular diseases such as atherosclerosis and hyperlipidemia, making it a promising target for drug development and personalized medicine approaches. Understanding the mechanisms of ANGPTL3 could lead to novel interventions for managing lipid disorders and reducing cardiovascular risk factors.

Product Name:ANGPTL3 Antibody
Product Sku:CPAB0057
Size:5μg
Host Species:Mouse
Immunogen:Anti-human ANGPTL3 mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human ANGPTL3 amino acids 243-46 purified from Ecoli.
Clone:P1D10AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:ANGPTL3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Angiopoietin-like proteins ANGPTL3 and ANGPTL4 are secreted proteins mainly expressed in liver that have been demonstrated to regulate triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. ANGPTL3 is structurally similar to angiopoietins, which are vascular endothelial growth factors. The experimental results show that Angptl3 and Angptl4 function to regulate circulating triglyceride levels during different nutritional states and therefore play a role in lipid metabolism during feeding/fasting through differential inhibition of Lipoprotein lipase (LPL). Using deletion mutants of Angiopoietin 5 human, it was demonstrated that the N-terminal domain containing fragment - (17€“207) and not the C-terminal fibrinogen-like domain containing fragment - (207€“460) increased the plasma triglyceride levels in mice.
Synonyms:Angiopoietin 5, ANGPT5, ANGPTL3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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