The Angiotensinogen Rabbit Monoclonal Antibody is a crucial tool for research involving angiotensinogen, a key protein in the renin-angiotensin system that regulates blood pressure and fluid balance in the body. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting angiotensinogen in human samples, making it an invaluable tool for studying the role of this protein in various physiological processes.Angiotensinogen is a precursor protein that plays a central role in the production of angiotensin peptides involved in blood pressure regulation, kidney function, and cardiovascular health. Dysregulation of the renin-angiotensin system is associated with various cardiovascular diseases, making angiotensinogen a target of interest for researchers studying hypertension, heart disease, and kidney disorders.
The Angiotensinogen Rabbit Monoclonal Antibody is validated for use in Western blotting and immunohistochemistry applications, allowing researchers to visualize and quantify angiotensinogen expression in different tissue types and cell lines. By understanding the mechanisms governing angiotensinogen production and activity, researchers can develop targeted therapies for managing conditions associated with renin-angiotensin system dysfunction.
Product Name:
Angiotensinogen Rabbit Monoclonal Antibody
SKU:
CAB11689
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Angiotensinogen (P01019).
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Purification Method:
Affinity purification
Gene ID:
183
Clone Number:
ARC0677
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse liver, using Angiotensinogen Rabbit mAb (CAB11689) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
