The Angiopoietin-1 Polyclonal Antibody (CAB7877) is a crucial tool for researchers studying the angiopoietin protein family, specifically Angiopoietin-1. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to Angiopoietin-1, this antibody enables researchers to detect and analyze the protein in a variety of cell types.Angiopoietin-1 is a key player in angiogenesis and vascular development, making it a promising target for studies related to cardiovascular disease, cancer, and other conditions involving abnormal blood vessel formation.
By understanding the function and regulation of Angiopoietin-1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic strategies.Overall, the Angiopoietin-1 Polyclonal Antibody (CAB7877) is a valuable tool for researchers interested in studying the role of Angiopoietin-1 in various physiological and pathological processes, with the potential to contribute to the development of novel treatment approaches in the future.
Product Name:
ANGPT1 Rabbit Polyclonal Antibody
SKU:
CAB7877
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 277-498 of human ANGPT1 (NP_001137.2).
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema.
Purification Method:
Affinity purification
Gene ID:
284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ANGPT1 Rabbit pAb (CAB7877) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
