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Androgen Receptor Transcription Factor Activity Assay

SKU:
TFAB00081
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Androgen Receptor
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

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Androgen Receptor Transcription Factor Activity Assay

The Androgen Receptor Transcription Factor Activity Assay Kit is specifically designed for the precise measurement of androgen receptor transcription factor activity in various biological samples. This kit offers exceptional sensitivity and specificity, guaranteeing accurate and consistent results for your research needs.The androgen receptor is a key transcription factor involved in regulating the expression of genes that control a variety of cellular processes, including growth, differentiation, and survival.

Dysregulation of androgen receptor activity has been linked to various diseases, including prostate cancer and androgen insensitivity syndrome.By using the Androgen Receptor Transcription Factor Activity Assay Kit, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially discover new therapeutic targets. This assay is an indispensable tool for studying androgen receptor function and developing novel treatments for related conditions.

Product Name:Androgen Receptor Transcription Factor Activity Assay
Product Code:TFAB00081
Target:Androgen Receptor
Synonyms:Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie Androgen Receptor transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:AR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Transcription factor; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: nucleoplasm; protein complex; cytoplasm; nuclear chromatin; nucleus

Molecular Function:protein dimerization activity; protein binding; ligand-dependent nuclear receptor activity; androgen receptor activity; enzyme binding; DNA binding; androgen binding; zinc ion binding; beta-catenin binding; chromatin binding; transcription factor binding; transcription factor activity; receptor binding

Biological Process: prostate gland development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of integrin biosynthetic process; cell proliferation; cell-cell signaling; transport; androgen receptor signaling pathway; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase III promoter; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of integrin biosynthetic process; cell growth; sex differentiation; positive regulation of phosphorylation

Disease: Androgen Insensitivity Syndrome; Prostate Cancer; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Spinal And Bulbar Muscular Atrophy, X-linked 1

NCBI Summary:The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P10275
NCBI GenInfo Identifier:113830
NCBI Gene ID:367
NCBI Accession:P10275.2
UniProt Secondary Accession:P10275,Q9UD95, A2RUN2, B1AKD7,
UniProt Related Accession:P10275
Molecular Weight:44,643 Da
NCBI Full Name:Androgen receptor
NCBI Synonym Full Names:androgen receptor
NCBI Official Symbol:AR  
NCBI Official Synonym Symbols:KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA  
NCBI Protein Information:androgen receptor; androgen nuclear receptor variant 2; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4
UniProt Protein Name:Androgen receptor
UniProt Synonym Protein Names:Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Protein Family:Allatostatin
UniProt Gene Name:AR  
UniProt Entry Name:ANDR_HUMAN
AntibodiesELISA Kits
Anti-Androgen Receptor Antibody (CAB0330)Human AR (Androgen Receptor) ELISA Kit (HUES01695)
Anti-Androgen Receptor Antibody (CAB16200)Androgen Receptor (Phospho-Ser650) Transcription Factor Activity Assay
Anti-Androgen Receptor Antibody (CAB19611)Androgen Receptor (Phospho-Tyr363) Transcription Factor Activity Assay
Anti-Androgen Receptor Antibody (CAB2053)
Anti-Phospho-Androgen receptor-S213 Antibody (CABP0306)

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