The Androgen Receptor Polyclonal Antibody is a valuable tool for research involving the androgen receptor, a key player in hormone signaling pathways and a known target for therapeutic interventions in conditions like prostate cancer. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications to detect and analyze the androgen receptor protein in various cell types.The androgen receptor is a transcription factor that mediates the effects of androgen hormones, playing a critical role in the development and progression of prostate cancer and other hormone-related disorders.
By targeting the androgen receptor, researchers can gain insights into the underlying mechanisms of these conditions and explore potential strategies for treatment and intervention.With its ability to specifically bind to the androgen receptor protein, this polyclonal antibody offers a valuable tool for studying the role of androgen signaling in health and disease. Whether investigating cancer biology, endocrinology, or drug development, researchers can rely on this antibody to facilitate their research and contribute to advancements in the field.
Product Name:
Androgen Receptor Rabbit Polyclonal Antibody
SKU:
CAB0330
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (NP_000035.2).
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
367
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Androgen Receptor Rabbit pAb (CAB0330) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
