The Androgen Receptor Rabbit Monoclonal Antibody (CAB19611) is a valuable tool for research involving the androgen receptor, a critical regulator of gene expression and cell growth in prostate cancer and other androgen-dependent tissues. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting the androgen receptor in human samples, providing reliable results for Western blotting and immunohistochemistry applications.The androgen receptor is a nuclear hormone receptor that plays a key role in the development and progression of prostate cancer, making it a target of interest for therapeutic interventions.
By targeting the androgen receptor, researchers can gain insights into the mechanisms underlying cancer growth and potentially identify new treatment strategies for hormone-sensitive cancers. The CAB19611 antibody enables precise detection and analysis of the androgen receptor in different cell types, offering researchers a powerful tool for advancing their studies in cancer biology and drug development.
Product Name:
Androgen Receptor Rabbit Monoclonal Antibody
SKU:
CAB19611
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (P10275).
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
367
Clone Number:
ARC0090
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse testis, using Androgen Receptor Rabbit mAb (CAB19611) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
