The Androgen Receptor Polyclonal Antibody (CAB2053) is a valuable tool for researchers studying the androgen receptor, a critical regulator of male reproductive development and function. This antibody, produced using rabbits, specifically targets the androgen receptor protein in human samples, making it ideal for use in Western blot applications.The androgen receptor plays a key role in mediating the effects of androgens, a class of hormones responsible for male characteristics and functions. Dysregulation of the androgen receptor has been implicated in various diseases, including prostate cancer and androgen insensitivity syndrome.
Understanding the expression and activity of the androgen receptor is essential for unraveling its role in disease pathology and identifying potential therapeutic targets.By utilizing the Androgen Receptor Polyclonal Antibody (CAB2053), researchers can accurately detect and quantify the androgen receptor in different cell types, advancing our knowledge of its function and potential implications in health and disease. This antibody is a valuable tool for those engaged in research related to endocrinology, reproductive biology, and cancer biology.
Product Name:
Androgen Receptor Rabbit Polyclonal Antibody
SKU:
CAB2053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (NP_000035.2).
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
367
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat testis, using Androgen Receptor antibody (CAB2053) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
