The ANAPC7 Polyclonal Antibody (CAB18459) is a valuable tool for researchers studying ANAPC7, a key protein involved in cell cycle regulation and protein degradation processes. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting the ANAPC7 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and cancer research.ANAPC7 is a component of the Anaphase-Promoting Complex (APC), a crucial regulator of cell division that ensures proper progression through the cell cycle.
Dysregulation of ANAPC7 has been implicated in diseases such as cancer, where aberrant cell proliferation and division can lead to tumor formation. Understanding the role of ANAPC7 in these processes is key to developing targeted therapies that can halt or reverse cell cycle abnormalities, making this antibody a valuable tool for researchers working in this field.
Product Name:
ANAPC7 Rabbit Polyclonal Antibody
SKU:
CAB18459
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ANAPC7 (NP_057322.2).
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51434
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using ANAPC7 Rabbit pAb (CAB18459) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
