null

ANAPC4 Antibody (PACO07728)

(No reviews yet) Write a Review
SKU:
PACO07728
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

system_update_altDatasheetsystem_update_altMSDS

ANAPC4 Antibody (PACO07728)

The ANAPC4 Polyclonal Antibody (PACO07728) is a valuable tool for researchers studying the ANAPC4 protein, a key component of the anaphase promoting complex/cyclosome (APC/C). This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it suitable for a variety of experimental applications, including Western blotting.ANAPC4 is essential for the regulation of cell cycle progression and overall cell division. Dysfunction of ANAPC4 has been associated with various diseases, including cancer, making it a target of interest for cancer research and drug development.

By using the ANAPC4 Polyclonal Antibody, researchers can investigate the role of ANAPC4 in cell cycle control, mitosis, and potential therapeutic interventions.With its ability to specifically bind to the ANAPC4 protein, this antibody enables precise detection and analysis in different cell types, providing valuable insights into cell cycle regulation mechanisms. Researchers in the fields of cell biology and oncology will find the ANAPC4 Polyclonal Antibody to be an indispensable tool for their studies and advancements in understanding disease pathways.

Antibody Name:ANAPC4 Antibody (PACO07728)
Antibody SKU:PACO07728
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human ANAPC4
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:anaphase promoting complex subunit 4;ANAPC4;APC4 ;
UniProt Protein Function:APC4: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC4 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: nucleoplasm; anaphase-promoting complex; nucleus; cytosol

Molecular Function:protein binding; ubiquitin-protein ligase activity; protein phosphatase binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle

NCBI Summary:A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Code:Q9UJX5
NCBI GenInfo Identifier:205371737
NCBI Gene ID:29945
NCBI Accession:Q9UJX5.2
UniProt Related Accession:Q9UJX5
Molecular Weight:
NCBI Full Name:Anaphase-promoting complex subunit 4
NCBI Synonym Full Names:anaphase promoting complex subunit 4
NCBI Official Symbol:ANAPC4  
NCBI Official Synonym Symbols:APC4  
NCBI Protein Information:anaphase-promoting complex subunit 4
UniProt Protein Name:Anaphase-promoting complex subunit 4
UniProt Synonym Protein Names:Cyclosome subunit 4
Protein Family:Acetophenone carboxylase
UniProt Gene Name:ANAPC4  
UniProt Entry Name:APC4_HUMAN

0 Reviews

View AllClose

Related Products