The ANAPC2 Polyclonal Antibody (CAB8066) is a powerful tool for researchers studying the ANAPC2 protein, a key component of the Anaphase Promoting Complex (APC). This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By targeting the ANAPC2 protein, this antibody enables the detection and analysis of ANAPC2 in various cell types, making it ideal for studies in cell cycle regulation and cancer research.The ANAPC2 protein is essential for proper cell division and the regulation of the cell cycle.
Dysregulation of the APC complex, in which ANAPC2 plays a critical role, is implicated in various diseases, including cancer. By understanding the function of ANAPC2, researchers can gain insights into the mechanisms of cell division and potentially develop targeted therapies for cancer treatment.Overall, the ANAPC2 Polyclonal Antibody is a valuable tool for researchers seeking to investigate the role of ANAPC2 in cell cycle regulation and cancer biology. Its specificity and reliability make it an essential component of any immunological or cancer research study.
Product Name:
ANAPC2 Rabbit Polyclonal Antibody
SKU:
CAB8066
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ANAPC2 (NP_037498.1).
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.
Purification Method:
Affinity purification
Gene ID:
29882
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ANAPC2 Rabbit pAb (CAB8066) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
