The ANAPC15 Polyclonal Antibody (PACO8072) is a valuable tool for research involving ANAPC15, a protein involved in cell cycle regulation. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the ANAPC15 protein, this antibody enables the detection and analysis of ANAPC15 in various cell types, making it ideal for studies in cell biology and cancer research.ANAPC15, also known as Anaphase-Promoting Complex Subunit 15, plays a crucial role in the regulation of cell division and ensuring the proper segregation of chromosomes during mitosis.
Its function in cell cycle control underscores its importance in processes such as cell proliferation and tumor development. Research into ANAPC15 can therefore provide valuable insights into the mechanisms underlying cancer and other proliferative disorders, ultimately aiding in the development of targeted therapies. By using the ANAPC15 Polyclonal Antibody, researchers can delve deeper into the functions and interactions of ANAPC15, paving the way for advancements in understanding cell cycle regulation and its implications in various disease states.
chromosome 11 open reading frame 51;C11orf51;DKFZp564M082;HSPC020 ;
UniProt Protein Function:
APC15: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. Belongs to the APC15 family.Chromosomal Location of Human Ortholog: 11q13.4Cellular Component: anaphase-promoting complex; cytosol; intracellular; nucleoplasmBiological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
