The AMZ1 Polyclonal Antibody (PACO19143) is a cutting-edge tool for researchers studying the AMZ1 protein, a key player in various cellular processes. This highly specific antibody, generated in rabbits, exhibits exceptional reactivity towards human samples and has been extensively validated for Western blot applications. By targeting the AMZ1 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an invaluable asset for investigations in molecular biology and cell signaling pathways.
AMZ1, also known as a crucial regulator of cellular functions, is involved in controlling cell growth, differentiation, and survival. Its importance in fundamental biological processes highlights its potential as a target for studying diseases such as cancer and metabolic disorders. By unraveling the intricate mechanisms involving AMZ1, researchers can uncover novel insights into disease pathogenesis and develop innovative therapeutic strategies for combating these conditions.
Antibody Name:
AMZ1 Antibody (PACO19143)
Antibody SKU:
PACO19143
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human AMZ1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, Human liver tissue, Primary antibody: PACO19143(AMZ1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
AMZ1 shares sequence similarity with archaeal metalloproteases called archaemetzincins, but it appears to act predominantly as a basic aminopeptidase. Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.
Synonyms:
archaelysin family metallopeptidase 1
UniProt Protein Function:
AMZ1: Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.Protein type: Protease; EC 3.-.-.-Chromosomal Location of Human Ortholog: 7p22.3
