The AMTN Polyclonal Antibody (PAC024896) is a valuable tool for researchers studying amelotin (AMTN), a protein involved in dental enamel formation and potentially linked to tooth development disorders. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the AMTN protein, this antibody allows for the precise detection and analysis of AMTN expression in various cell types, making it ideal for studies in dental research and developmental biology.
AMTN is a protein that has been shown to play a crucial role in enamel mineralization and tooth development. Understanding the function and regulation of AMTN is essential for gaining insights into dental pathologies, such as enamel defects and tooth malformations. By elucidating the mechanisms by which AMTN contributes to enamel formation, researchers can potentially identify new therapeutic targets for treating dental disorders and improving oral health outcomes.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO24896 at dilution of 1:100.
Background:
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
Synonyms:
Amelotin, AMTN
UniProt Protein Function:
AMTN: Could be a cell adhesion protein involved in the maturation of tooth enamel. Belongs to the amelotin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Extracellular matrix; Secreted; Secreted, signal peptide; Cell adhesionChromosomal Location of Human Ortholog: 4q13.3Cellular Component: basal lamina; intercellular junction; proteinaceous extracellular matrixBiological Process: odontogenesis of dentine-containing teeth
UniProt Protein Details:
NCBI Summary:
The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
