The AMPKbeta1 Rabbit Monoclonal Antibody (CAB4344) is a crucial tool for researchers studying the AMP-activated protein kinase (AMPK) signaling pathway. This antibody, produced in rabbits, specifically binds to the AMPKbeta1 subunit, allowing for precise detection and analysis in various cell types and tissues.The AMPK signaling pathway plays a vital role in cellular energy homeostasis, regulating processes such as metabolism, cell growth, and autophagy. Dysregulation of AMPK has been implicated in a variety of diseases, including diabetes, cancer, and neurological disorders.
By targeting the AMPKbeta1 subunit, researchers can gain valuable insights into the function of AMPK in these disease contexts.This antibody is validated for use in Western blot applications, providing reliable data for experimental analyses. Its high reactivity with human samples makes it an ideal choice for studies in molecular biology, biochemistry, and drug development. With the AMPKbeta1 Rabbit Monoclonal Antibody (CAB4344), researchers can advance their understanding of AMPK signaling and potentially identify new therapeutic targets for a range of diseases.
Product Name:
AMPKβ1 Rabbit Monoclonal Antibody
SKU:
CAB4344
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human AMPKβ1 (Q9Y478).
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Purification Method:
Affinity purification
Gene ID:
5564
Clone Number:
ARC1061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using AMPKβ1 Rabbit mAb (CAB4344) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
