AMPKβ1 Rabbit Monoclonal Antibody (CAB4344)
- SKU:
- CAB4344
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | AMPKβ1 Rabbit Monoclonal Antibody |
SKU: | CAB4344 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human AMPKβ1 (Q9Y478). |
Sequence: | EEIK APEK EEFL AWQH DLEV NDKA PAQA RPTV FRWT GGGK EVYL SGSF NNWS KLPL TRSH NNFV AILD LPEG EHQY KFFV DGQW THDP SEPI VTSQ LGTV N |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AMPK; HAMPKb; AMPKβ1 |
Positive Sample: | Mouse brain,Rat lung,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleoplasm, nucleus |
Calculated MW: | 30kDa |
Observed MW: | 38kDa |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Purification Method: | Affinity purification |
Gene ID: | 5564 |
Clone Number: | ARC1061 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |