The PRSS50 Polyclonal Antibody (PAC020776) is a valuable tool for researchers studying PRSS50, a protein involved in skin development and keratinocyte differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.PRSS50 is a serine protease that plays a crucial role in the maintenance of skin barrier function and the regulation of epidermal differentiation. Dysregulation of PRSS50 has been associated with skin disorders such as atopic dermatitis and psoriasis, highlighting its importance in skin biology.
Research using the PRSS50 antibody can provide insights into the molecular mechanisms underlying these conditions and aid in the development of novel therapeutic strategies.The PRSS50 Polyclonal Antibody is a valuable tool for investigators interested in unraveling the complex processes governing skin development and barrier function. By targeting PRSS50, researchers can delve deeper into the intricate pathways involved in epidermal homeostasis and potentially identify new targets for therapeutic intervention in skin diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20776(PRSS50 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Hepg2 cells, Primary antibody: PACO20776(PRSS50 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20776(PRSS50 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
May be involved in proteolysis through its threonine endopeptidase activity. Testis specific. Differentially expressed in some breast cancer tissues.
Synonyms:
protease, serine, 50
UniProt Protein Function:
TSP50: May be involved in proteolysis through its threonine endopeptidase activity. Belongs to the peptidase S1 family.Protein type: EC 3.4.25.-; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 3p21.31Cellular Component: endoplasmic reticulum; cytoplasmMolecular Function: threonine endopeptidase activity; serine-type endopeptidase activityBiological Process: proteolysis
