The AmotL2 Polyclonal Antibody (CAB16723) is a valuable tool for researchers studying the AmotL2 protein, which is involved in various cellular processes, including cell polarity and cell migration. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in immunohistochemistry and immunofluorescence applications.AmotL2, also known as angiomotin-like protein 2, is a key player in the Hippo signaling pathway, which controls organ size and tissue homeostasis. Dysregulation of this pathway has been implicated in cancer development and progression, making AmotL2 a promising target for cancer research.
By detecting and analyzing the AmotL2 protein in different cell types, this antibody enables researchers to further understand its role in tumorigenesis and potentially develop targeted therapies for cancer treatment.Overall, the AmotL2 Polyclonal Antibody (CAB16723) is a valuable asset for researchers interested in unraveling the functions of the AmotL2 protein in various biological processes, particularly in the context of cancer biology and signal transduction pathways. Its specificity and reliability make it an essential tool for advancing scientific knowledge and exploring potential therapeutic strategies.
Product Name:
AMOTL2 Rabbit Polyclonal Antibody
SKU:
CAB16723
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 638-837 of human AMOTL2 (NP_001265612.1).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
51421
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from BeWo cells using AMOTL2 Rabbit pAb(CAB16723) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time:60s.
