The AMMECR1 Polyclonal Antibody (PAC057036) is specifically designed for research involving AMMECR1, a protein involved in the regulation of immune responses and inflammation. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the AMMECR1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.AMMECR1, also known as a key regulator of immune function, plays a crucial role in maintaining immune homeostasis and modulating inflammatory responses.
Its involvement in immune regulation makes it a promising target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the role of AMMECR1 is essential for developing therapeutic strategies that target or manipulate immune responses in these disease contexts. Overall, the AMMECR1 Polyclonal Antibody (PAC057036) is a valuable tool for researchers investigating the function of AMMECR1 in immune regulation and its potential implications in various pathological conditions.
IHC image of PACO57036 diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO57036 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO57036 diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
nucleus
Synonyms:
AMME syndrome candidate gene 1 protein, AMMECR1
UniProt Protein Function:
AMMECR1: Defects in AMMECR1 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. 4 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xq22.3Molecular Function: protein bindingDisease: Amme Complex
UniProt Protein Details:
NCBI Summary:
The exact function of this gene is not known, however, submicroscopic deletion of the X chromosome including this gene, COL4A5, and FACL4 genes, result in a contiguous gene deletion syndrome, the AMME complex (Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
