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CD13/ANPEP Rabbit Polyclonal Antibody (CAB5662)

SKU:
CAB5662
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
  • Cardiovascular Antibodies Anti-ANPEP Antibody CAB5662
  • Cardiovascular Antibodies Anti-ANPEP Antibody CAB5662
  • Cardiovascular Antibodies Anti-ANPEP Antibody CAB5662
  • Cardiovascular Antibodies Anti-ANPEP Antibody CAB5662
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CD13/ANPEP Rabbit Polyclonal Antibody
SKU:CAB5662
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 668-967 of human CD13/CD13/ANPEP (NP_001141.2).
Sequence:LASA HKVP VTLA LNNT LFLI EERQ YMPW EAAL SSLS YFKL MFDR SEVY GPMK NYLK KQVT PLFI HFRN NTNN WREI PENL MDQY SEVN AIST ACSN GVPE CEEM VSGL FKQW MENP NNNP IHPN LRST VYCN AIAQ GGEE EWDF AWEQ FRNA TLVN EADK LRAA LACS KELW ILNR YLSY TLNP DLIR KQDA TSTI ISIT NNVI GQGL VWDF VQSN WKKL FNDY GGGS FSFS NLIQ AVTR RFST EYEL QQLE QFKK DNEE TGFG SGTR ALEQ ALEK TKAN IKWV KENK EVVL QWFT ENSK
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100
Synonyms:APN; AP-M; AP-N; CD13; LAP1; P150; PEPN; hAPN; GP150; CD13/ANPEP
Positive Sample:OVCAR3,Mouse kidney,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytosol.
Calculated MW:110kDa
Observed MW:150kDa

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.

Purification Method:Affinity purification
Gene ID:290
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using CD13/ANPEP Rabbit pAb (CAB5662) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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