The AMIGO2 Polyclonal Antibody (PAC037286) is a valuable tool for researchers studying the AMIGO2 protein and its role in cellular communication and signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.AMIGO2, also known as Alivin1 and Amphoterin-induced gene and ORF, is a transmembrane protein involved in cell adhesion and neurite outgrowth. It is essential for the development and function of the nervous system, making it a key player in neurobiology research. The AMIGO2 Polyclonal Antibody binds specifically to the AMIGO2 protein, allowing for its detection and analysis in different cell types and tissues.
Research on AMIGO2 is crucial for understanding its role in neural development, synaptic plasticity, and neurological disorders. By elucidating the mechanisms by which AMIGO2 functions, researchers can uncover potential therapeutic targets for neurological conditions such as Alzheimer's disease, epilepsy, and developmental disorders. The AMIGO2 Polyclonal Antibody is a valuable tool for advancing our knowledge of AMIGO2 and its implications in neuroscience research.
Western Blot. Positive WB detected in: Rat liver tissue. All lanes: AMIGO2 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa.
IHC image of PACO37286 diluted at 1:800 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO37286 diluted at 1:800 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Synonyms:
Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA), AMIGO2, ALI1
UniProt Protein Function:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
