Anti-AMIGO2 Antibody (PACO15421)

Antibody Name:	AMIGO2 Antibody (PACO15421)
Antibody SKU:	PACO15421
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human AMIGO2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15421(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: SP20 cells, mouse heart tissue, Primary antibody: PACO15421(AMIGO2 Antibody) at dilution 1/615, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15421(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction

Synonyms:

adhesion molecule with Ig-like domain 2

UniProt Protein Function:	Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q86SJ2
NCBI GenInfo Identifier:	219521831
NCBI Gene ID:	347902
NCBI Accession:	NP_001137140.1
UniProt Secondary Accession:	Q86SJ2,Q4VBP6, Q7Z4A0, Q96CN8
UniProt Related Accession:	Q86SJ2
Molecular Weight:	57
NCBI Full Name:	amphoterin-induced protein 2
NCBI Synonym Full Names:	adhesion molecule with Ig like domain 2
NCBI Official Symbol:	AMIGO2
NCBI Official Synonym Symbols:	ALI1; DEGA; AMIGO-2
NCBI Protein Information:	amphoterin-induced protein 2
UniProt Protein Name:	Amphoterin-induced protein 2
UniProt Synonym Protein Names:	AMIGO-2; Alivin-1; Differentially expressed in gastric adenocarcinomas; DEGA
Protein Family:
UniProt Gene Name:	AMIGO2
UniProt Entry Name:

Antibodies

AMIGO2 Antibody (PACO07715)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)