The AMIGO2 Polyclonal Antibody (PAC015421) is a vital tool for researchers studying AMIGO2, a cell adhesion molecule that plays a key role in neuronal development and function. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the AMIGO2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an excellent choice for studies in neurobiology and neuroscience.AMIGO2 is an important regulator of neuronal growth and connectivity in the brain, making it a promising target for research into neurological disorders such as Alzheimer's disease, autism, and schizophrenia.
By understanding the functions of AMIGO2, researchers can uncover new insights into the mechanisms underlying these conditions and potentially develop novel therapeutic approaches to treat them.Overall, the AMIGO2 Polyclonal Antibody is a valuable tool for researchers seeking to explore the role of AMIGO2 in neuronal development and neurological disorders. Its high reactivity and specificity make it an essential component of any study aiming to unravel the complexities of the brain and its functions.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15421(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: SP20 cells, mouse heart tissue, Primary antibody: PACO15421(AMIGO2 Antibody) at dilution 1/615, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15421(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction
Synonyms:
adhesion molecule with Ig-like domain 2
UniProt Protein Function:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
